Does Mycn alleviate cardiac hypertrophy-induced heart failure in mice?
Mycn protects against cardiac hypertrophy-induced heart failure in mice via the USP2/JUP/Akt/β-catenin pathway.
This study demonstrates that Mycn activates USP2 transcription, which mediates ubiquitination and protein stabilization of JUP, thus inactivating the Akt/β-catenin axis and alleviating cardiac hypertrophy-induced heart failure.
Gao et al. (Wed,) studied this question.
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