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Research Paper | Synapse

February 3, 2024Open Access

Circulating Biomarkers of Endothelial Dysfunction Associated With Ventilatory Ratio and Mortality in ARDS Resulting From SARS-CoV-2 Infection Treated With Antiinflammatory Therapies

JAJehan AlladinaHarvard University FGFrancesca GiaconaMassachusetts General Hospital AHAlexis M. HaringMassachusetts General Hospital

Key Points

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Abstract

Biomarkers of inflammation, coagulation, and epithelial injury were not associated with clinical outcomes in a small cohort of patients with ARDS uniformly treated with immunomodulators. However, endothelial biomarkers, including plasma NEDD9, were associated with 60-day mortality.

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Alladina et al. (Sat,) studied this question.

synapsesocial.com/papers/69d8c939183921ebcaae3ac8 https://doi.org/https://doi.org/10.1016/j.chstcc.2024.100054

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3Ventilation with Lower Tidal Volumes as Compared with Traditional Tidal Volumes for Acute Lung Injury and the Acute Respiratory Distress Syndrome2000 · 12,953 citations
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5Pulmonary endothelial NEDD9 and the prothrombotic pathophenotype of acute respiratory distress syndrome due to SARS‐CoV‐2 infection2022 · 12 citations