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Background: First-generation antipsychotics are dopamine receptor antagonists, while second-generation atypical antipsychotics are serotonin-dopamine antagonists. Aim: The study aims to compare the effectiveness of current anti-psychotic drugs in treating schizophrenia, focusing on their correlation with responsiveness rates in positive, negative, and psychopathological symptoms. Methods: The study focuses on schizophrenia-spectrum disorders in adults and elderly psychiatric patients at the Princess Aisha Bint Al Hussein Medical Centre. The study will assess the initial severity of patients and evaluate the therapeutic effectiveness of four categorical-based oral and LA-APDs: older oral drugs, older oral and depot drugs, newer oral drugs, and newer oral and depot drugs. The reduction percentages in each component will be monitored, and a Chi Square test will be performed to analyze other variables. Pearson or spearman correlations will be used to explore correlation values. Results: Upon aggregating the various symptom categories into a unified score using the Positive and Negative Scoring Scale (PANSS), this study revealed that 63.7% of patients exhibited a positive response, whereas 36.7% of patients did not respond favourably. This equated to 110 out of 303 patients responding, compared to 193 patients who did not respond. The Pearson and Spearman correlations exhibited a statistically significant positive relationship, with values of +0.581±0.038 and +0.574±0.040, respectively (χ 2=131.885, p-value=0.000). Conclusion: Our study concluded that Psychopathological symptom therapy and patient adherence improved significantly. The efficiency of pleasant symptoms decreased significantly, whereas negative symptoms increased slightly.
Alasasleh et al. (Fri,) studied this question.