Key points are not available for this paper at this time.
Abstract Purpose We introduced a novel reconstruction network, jointly unrolled cross‐domain optimization‐based spatio‐temporal reconstruction network (JUST‐Net), aimed at accelerating 3D multi‐echo gradient‐echo (mGRE) data acquisition and improving the quality of resulting myelin water imaging (MWI) maps. Method An unrolled cross‐domain spatio‐temporal reconstruction network was designed. The main idea is to combine frequency and spatio‐temporal image feature representations and to sequentially implement convolution layers in both domains. The k‐space subnetwork utilizes shared information from adjacent frames, whereas the image subnetwork applies separate convolutions in both spatial and temporal dimensions. The proposed reconstruction network was evaluated for both retrospectively and prospectively accelerated acquisition. Furthermore, it was assessed in simulation studies and real‐world cases with k‐space corruptions to evaluate its potential for motion artifact reduction. Results The proposed JUST‐Net enabled highly reproducible and accelerated 3D mGRE acquisition for whole‐brain MWI, reducing the acquisition time from fully sampled 15:23 to 2:22 min within a 3‐min reconstruction time. The normalized root mean squared error of the reconstructed mGRE images increased by less than 4.0%, and the correlation coefficients for MWI showed a value of over 0.68 when compared to the fully sampled reference. Additionally, the proposed method demonstrated a mitigating effect on both simulated and clinical motion‐corrupted cases. Conclusion The proposed JUST‐Net has demonstrated the capability to achieve high acceleration factors for 3D mGRE‐based MWI, which is expected to facilitate widespread clinical applications of MWI.
Lee et al. (Sun,) studied this question.