The Intestinal-type adenocarcinoma of nasal cavity: Report of two cases and Literature Review

Abstract Introduction: Sinonasal intestinal-type adenocarcinoma (ITACs) are rare high-grade epithelial tumours of the nose and paranasal sinuses. It's a fast-growing tumour having morphological, immunophenotypic, and molecular similarities to primary colonic adenocarcinoma, with a yearly incidence of less than 1 case per 100,000 people. Males are more affected than females as a result of work exposures. Wood and leather dust, as well as other chemical compounds, have been identified as causative factors in the literature. Unilateral or bilateral nasal obstruction, epistaxis, and possibly rhinorrhoea are signs and symptoms of sinonasal malignancies, which are similar to chronic sinus inflammation. As a result, all of these hazy symptoms add up to a diagnostic roadblock. Because of the rarity and diversity of histological types, there is a scarcity of information on treatment methods. Case Presentation: Herein we are presenting two rare examples of mixed ITAC in a 35-year-old male farmer and a 28-year-old house wife who presented with symptoms of nasal bleeding. We have described clinical-pathological features along with current breakthroughs in molecular pathologic aspects in the literature. Conclusion Diagnosis of Sinonasal ITACs a rare type of neoplasm that can only be diagnosed by a pathological report. Symptoms of sinus infiltrates include: Nasal obstruction Epistaxis Rhinorrhea However, it is possible to present with a benign, palpable mass. ITACs should be considered in the differential diagnosis of nasal polypoidal lesions. The case report and literature review include information on histomorphological characteristics, differential diagnostic criteria, molecular characteristics, treatment options, and ITAC prognosis.