Supplementary Figure S2 from Pim Kinase Inhibitors Increase Gilteritinib Cytotoxicity in FLT3-ITD Acute Myeloid Leukemia Through GSK-3β Activation and c-Myc and Mcl-1 Proteasomal Degradation

Concurrent Pim and FLT3 inhibitor treatment inhibits AKT, but GSK-3β activation, c-Myc and Mcl-1 downregulation and apoptosis induction are independent of AKT inhibition as well as ERK inhibition.