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Abstract Background This study aimed to investigate the effect of erbium, chromium doped:yttrium,scandium,gallium,garnet (Er,Cr:YSGG) laser application combined with non‐surgical mechanical debridement (MD) on clinical parameters and peri‐implant crevicular fluid receptor activator of nuclear factor‐kappa B ligand (RANKL) and osteoprotegerin (OPG) levels in the treatment of peri‐implantitis. Methods A total of 49 patients who underwent non‐surgical treatment of peri‐implantitis were randomly divided into two groups. The control group ( n = 26) received MD alone, while the laser group ( n = 23) received MD+Er,Cr:YSGG. The clinical parameters (bleeding on probing BoP, gingival index GI, plaque index PI, probing depth PD), marginal bone loss (MBL), and biochemical parameters (RANKL and OPG) were measured at baseline (T0) and 6 months after treatment (T1). Results There was a statistically significant decrease in all the clinical parameters in both groups at T1 compared to T0 ( p < 0.05). The BoP, PD, MBL, and RANKL reductions were significantly higher in the laser group than in the control group ( p = 0.046, p = 0.014, p = 0.047, p = 0.045, respectively). The OPG levels significantly increased at T1 in the laser group ( p = 0.01). The OPG/RANKL ratio increased significantly in both groups at T1, which favored the laser group ( p = 0.034). Conclusions Although both treatment methods were influential in treating peri‐implantitis, the laser group (MD+Er,Cr:YSGG) yielded more favorable results by reducing clinical inflammation and improving biochemical parameters. Based on these findings, Er,Cr:YSGG laser may be a beneficial adjunctive treatment in this patient group.
Yaylı et al. (Tue,) studied this question.