Brain natriuretic peptide levels were significantly elevated (MD 2.57; 95% CI 1.35-3.78) and glomerular filtration rate was reduced in patients with acute heart failure.
Meta-Analysis
Are brain natriuretic peptide (BNP) and glomerular filtration rate (GFR) levels altered in patients with acute heart failure?
This meta-analysis confirms that acute heart failure is associated with significantly elevated BNP levels and reduced glomerular filtration rate.
Effect estimate: MD 2.57 (95% CI 1.35, 3.78)
BACKGROUND: Acute heart failure (AHF) is one of the most common cardiovascular diseases. Early diagnosis and prognosis are essential, as they can eventually lead to a fatal condition. Recently, brain natriuretic peptide (BNP) has been recognized as one of the most popular biomarkers for AHF. Changes in glomerular filtration rate (GFR) are often observed in AHF. METHODS: We searched PubMed, Google Scholar, and ScienceDirect between March and June 2023. Original case control studies written in English that assessed levels oh BNP in AHF were included. Systematic reviews, letters to editor, correspondence, comprehensive reviews, and duplicated studies were excluded. Funnel plots were constructed to assess publication bias. RESULTS: A total of 9 studies were selected and we obtained the mean difference (MD) of BNP level to be 2.57 (95% CI: 1.35, 3.78), and GFR to be -15.52, (95% CI: -23.35, -7.70) in AHF patients. Sensitivity analyses supported the robustness of the outcome. CONCLUSION: Results indicated that BNP was a promising prognostic biomarker of AHF, whereas GFR was found to be negatively correlated with AHF.
Mughal et al. (Fri,) conducted a meta-analysis in Acute heart failure. Brain natriuretic peptide (BNP) and glomerular filtration rate (GFR) assessment was evaluated on Mean difference in BNP level (MD 2.57, 95% CI 1.35, 3.78). Brain natriuretic peptide levels were significantly elevated (MD 2.57; 95% CI 1.35-3.78) and glomerular filtration rate was reduced in patients with acute heart failure.