Volatile components of ethyl acetate extracts from the leaves and rhizomes of Curcuma sahuynhensis and their cytotoxic activity: In vitro and in silico studies

Curcuma sahuynhensis Škorničk. neophytadiene; 3,7,11,15-tetramethyl-2-hexadecen-1-ol; acetic acid, 3,7,11,15-tetramethyl-hexadecyl ester; isoborneol; methyl palmitate, were found in the leaf extract. Meanwhile, eucalyptol; ambrial; (E)-labda-8(17),12-diene-15,16-dial; α-copaene; trans-β-ionone; isolongifolol, acetate; and isobornyl formate were the main components in the rhizome extract. On five human cancer cell lines (MFC-7, SK-LU-1, Hela, MKN-7, and HL-60), the leaf and rhizome extracts showed concentration-dependent manner cytotoxic activity, with IC50 values ranging from 126.11±8.27 to 254.82±10.25 µg/mL for leaf extract and IC50 values ranging from 109.30±6.75 to 184.59±10.24 µg/mL for rhizome extract. Compounds (E)-labda-8(17),12-diene-15,16-dial (19), isolongifolol, acetate (10) and diisooctyl phthalate (20) were identified as potential inhibitors of epidermal growth factor receptors based on computational analysis. The findings of this work might offer an experimental foundation for further research on the isolation of metabolites and their in vivo cytotoxicity related to "vegetable turmeric" resources.