Drug-coated balloons provide an effective treatment for in-stent restenosis, with growing evidence from long-term follow-up supporting their use in de novo lesions and complex bifurcations.
Do drug-coated balloons improve clinical outcomes in patients with various coronary artery disease scenarios compared to traditional metallic stents?
Drug-coated balloons represent a promising and increasingly supported strategy for treating in-stent restenosis and various de novo coronary lesions without leaving a permanent prosthesis.
Continuous advances in the field of interventional cardiology have led to the development of drug-coated balloons (DCB). These represent a promising device for overcoming the well-known limitations of traditional metallic stents, which are associated with a persistent yearly increased risk of adverse events. This technology has the ability to homogeneously transfer the drug into the vessel wall in the absence of a permanent prosthesis implanted in the coronary vessel. Robust data support the use of DCB for the treatment of in-stent restenosis, but there is also currently growing evidence from long-term follow-up of large randomised clinical trials regarding the use of these devices in other scenarios, such as de novo small and large vessel disease, complex bifurcations, and diffuse coronary disease. Other critical clinical settings such as diabetes mellitus, high bleeding risk patients and acute coronary syndromes could be approached in the upcoming future by using DCB, alone or as part of a blended strategy in combination with drug-eluting stents. There have been important scientific and technical advances in the DCB field in recent years. The purpose of this paper is to review the most current data regarding the use of DCB, including the mid- and long-term follow-up reports on the safety and efficacy of this novel strategy in different clinical and angiographic scenarios.
Lazăr et al. (Thu,) conducted a review in Coronary artery disease. Drug-coated balloons was evaluated. Drug-coated balloons provide an effective treatment for in-stent restenosis, with growing evidence from long-term follow-up supporting their use in de novo lesions and complex bifurcations.