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Bicyclo1.1.0butanes (BCBs) and 1.1.1propellanes (tricyclo1.1.1.01,3pentanes, TCPs) are structurally unique compounds with different chemical properties. Strain-release driven reactions have emerged as an atom- and step-economic strategy for the organic synthesis. Using this strategy, a variety of functional ring molecules have been efficiently synthesized, including various cyclobutane molecules, bicyclo2.1.1hexanes, bicyclo1.1.1pentanes, and others. More specifically, these strain release-driven reactions include aspects of nucleophilic addition, radical addition, electrophilic or transition metal catalysis. This review will discuss the recent developments in the strain-release transformations of bicyclo1.1.0butanes and 1.1.1propellanes.
Hu et al. (Wed,) studied this question.