Temporal trends in colorectal cancer mortality rates (1999–2022) in the United States

Abstract Colorectal cancer (CRC) ranks as the third leading cause of cancer‐related deaths in the United States (U.S.). Our study aims to analyze CRC mortality patterns in the U.S., focusing on gender and age groups from 1999 to 2022. We analyzed Age‐Adjusted Mortality Rates (AAMRs) for CRC‐related deaths using the CDC Wide‐ranging Online Data for Epidemiologic Research (CDC WONDER) database and assessed differences between age and sex. CRC‐related mortality decreased significantly from 1999 to 2011 (−2.81% APC) and from 2011 to 2020 (−1.95% APC) but a not significant uptrend from 2020 to 2022 (2% APC). Males experienced a more significant decrease. Among age groups, crude mortality decreased until 2020, except in age group 45–54, which showed an annual increase in mortality of 0.9% from 2004 to 2022. Furthermore, individuals aged 75–84 and 85+ saw a nonsignificant annual increase of 1.8% and 4.5% from 2020 to 2022, respectively. Our study highlights a significant decline in age and gender‐specific CRC‐related mortality from 1999 to 2020. However, the worrisome uptrend observed in the younger age group of 45–54 emphasizes the importance of implementing targeted public health measures and evidence‐based interventions.