Rationally Designed Benzobisthiadiazole‐Based Covalent Organic Framework for High‐Performance NIR‐II Fluorescence Imaging‐Guided Photodynamic Therapy

Although being applied as photosensitizers for photodynamic therapy, covalent organic frameworks (COFs) fail the precise fluorescence imaging in vivo and phototherapy in deep-tissue, due to short excitation/emission wavelengths. Herein, this work proposes the first example of NIR-II emissive and benzobisthiadiazole-based COF-980. Comparing to its ligands, the structure of COF-980 can more efficiently reducing the energy gap (ΔE