Variants in BRCA1/2 in a hospital-based cohort in Chile and national literature review.

Introduction: Oncoplastic breast surgery includes volume replacement as well as volume displacement.Autologous tissue is the preferred approach for volume replacement and includes chest wall perforator flaps (CWPF).Although described more than a decade ago, CWPFs have not been adopted widely in clinical practice till recently.We report the largest single-centre institutional data on CWPFs. Patients and methods:The study includes all patients who underwent breast conservation surgery (BCS) using CWPFs from January 2015 to December 2022.Data were retrieved from the institutional electronic record and Redcap database.The analysis was done using SPSS 23 and STATA 14.Results: 150 patients were included in the study.The mean age was 48.8 years (SD 10.4), and the body mass index was (26.6 kg/m 2 , SD 4.3).>50% of patients had breasts with small cup sizes (A&B) and mild ptosis (Non-ptotic and Grade 1 ptosis).44.7% of patients underwent lateral intercostal artery perforator flap (LICAP), anterior intercostal artery perforator flap in 31.3%, lateral thoracic perforator flap (LTAP) in 12%, LICAP + LTAP in 11.3% and thoracodorsal artery perforator flap in 1%.Post-operatively, haematoma was seen in 1.3%, complete flap necrosis in 1.3%, seroma in 7%, wound dehiscence in 12%, and positive margin in 6.7%.92 patients responded to the satisfaction assessment, of which >90% were happy with the surgical scars, comfortable going out in a public place, satisfied with the symmetry of the breast, and no one chose mastectomy in hindsight.The 5-year predicted disease free survival and overall survival were 86.4% and 94.7%, respectively. Conclusion:BCS with CWPF is an excellent option for reconstruction in small to mediumsized breasts.It is associated with minimal morbidity and comparable patient-reported cosmetic and survival outcomes.