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Radiotherapy is a common treatment approach for millions of patients with cancer each year. As a result, there is a need for effective radiation mitigation strategies. Scientists have investigated agents with reduced toxicity for improving radioprotection and potential mitigation of the harmful effects of ionizing radiation exposure. Natural antioxidants have shown promising results as radioprotectors that can be administered at high doses with low toxicity. The main mechanisms of radiation protection with natural antioxidants involve the scavenging of free radicals, the management of inflammatory responses, and the attenuation of apoptosis signaling pathways in radiosensitive organs. By exploring the potential of various antioxidants, researchers aim to enhance their radioprotective effects and minimize the adverse consequences of ionizing radiation exposure.
Ahmed Saleh (Tue,) studied this question.