Motility driven glassy dynamics in confluent epithelial monolayers

As wounds heal, embryos develop, cancer spreads, or asthma progresses, the cellular monolayer undergoes glass transition between solid-like jammed and fluid-like flowing states. During some of these processes, the cells undergo an epithelial-to-mesenchymal transition (EMT): they acquire in-plane polarity and become motile. Thus, how motility drives the glassy dynamics in epithelial systems is critical for the EMT process. However, no analytical framework that is indispensable for deeper insights exists. Here, we develop such a theory inspired by a well-known glass theory. One crucial result of this work is that the confluency affects the effective persistence time-scale of active force, described by its rotational diffusivity, Dᵣ^eff. Dᵣ^eff differs from the bare rotational diffusivity, Dᵣ, of the motile force due to cell shape dynamics, which acts to rectify the force dynamics: Dᵣ^eff is equal to Dᵣ when Dᵣ is small and saturates when Dᵣ is large. We test the theoretical prediction of Dᵣ^eff and how it affects the relaxation dynamics in our simulations of active Vertex model. This novel effect of Dᵣ^eff is crucial to understanding the new and previously published simulation data of active glassy dynamics in epithelial monolayers.