PIPETS: A statistically informed, gene-annotation agnostic analysis method to study bacterial termination using 3’-end sequencing

Over the last decade the drop in short-read sequencing costs has allowed experimental techniques utilizing sequencing to address specific biological questions to proliferate, oVentimes outpacing standardized or effective analysis approaches for the data generated. There are growing amounts of bacterial 3'-end sequencing data, yet there is currently no commonly accepted analysis methodology for this datatype. Most data analysis approaches are somewhat