Abstract 4822: Disparities in receiving non-surgical therapy impact outcomes in non-metastatic gastric cancer in Louisiana

Abstract Background: Given the history of evolving medical therapies and advancements in cancer treatments over the last decades, resectable gastric cancer has presented multiple strategies for care. Previous literature indicates historically decreased use of multimodal therapies in minority populations. This study aims to evaluate Louisiana patient populations for rates of definitive treatment, inequities in access to care, and evaluating its impact on the outcomes of minorities and underserved population. Methods: Patients with non-metastatic primary invasive gastric cancer, with T2-4 or any T status with positive lymph nodes, were identified in the Louisiana Tumor Registry using ICD-O codes and AJCC staging system. Receipt of non-surgical therapy was modeled using logistic regression. Overall survival (OS) was modeled using a Cox proportional hazards model. Results: The study included 561 patients, of which 37. 6% (n=211) did not receive surgical treatment and 16. 2% (n=91) did not receive non-surgical therapy. A subset of the cohort received no definitive treatment, (6. 8%, n=38). In a demographic only multivariable model, adjusting for age, sex, and race, age 70 and over OR (95%CI) =0. 18 (0. 08-0. 42), p0. 001 and female sex OR (95%CI) =0. 48 (0. 28-0. 85), p=0. 011 was associated with decreased rates of non-surgical therapy. Black OR (95%CI) = 0. 54 (0. 31-0. 93), p=0. 027 and Hispanic OR (95%CI) = 0. 38 (0. 13-1. 08), p=0. 070 race was associated with decreased receipt of non-surgical therapies. However, after adjusting for domestic partner, insurance status, rurality, area poverty, and surgery status, racial disparities were no longer significant compared to whites: Black OR (95% CI) = 0. 59 (0. 33-1. 06), p=0. 075; Hispanic OR (95% CI) = 0. 52 (0. 17-1. 66), p=0. 272. In multivariable analyses, receipt of surgery HR (95% CI) = 0. 3 (0. 23 - 0. 38), p0. 001) and any non-surgical therapy [HR (95% CI) = 0. 43 (0. 31 - 0. 60), p0. 001) were associated with increased overall survival. Conclusion: A significant number of patients did not receive all modalities of the multidisciplinary treatment that is recommended for patients with non-metastatic gastric adenocarcinoma. Black patients and females are less likely to receive non-surgical modalities for gastric cancer in Louisiana, which is, at least, partially driven by socioeconomic determinants. Identifying patients with these risk factors is a crucial step in allocating resources to increase access the care and improve outcomes. Citation Format: Conner D. Hartupee, Kyla Maupin, Denise M. Danos, Omeed Moaven. Disparities in receiving non-surgical therapy impact outcomes in non-metastatic gastric cancer in Louisiana [abstract. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts) ; 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84 (6Suppl): Abstract nr 4822.