Key points are not available for this paper at this time.
Our immune system possesses sophisticatedmechanisms to cope with invading microorganisms, while pathogensevolve strategies to deal with threats imposed by host immunity. Thehuman plasma protein α1-antitrypsin (AAT) exhibits pleiotropicimmune-modulating properties by both preventing immunopathology andimproving antimicrobial host defence. Genetic associations suggesteda role for AAT in candidemia, the most frequent fungal bloodstreaminfection in the ICU, yet little is known about how AAT influencesinteractions between Candidaalbicans and the immunesystem.
Jaeger et al. (Fri,) studied this question.