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Here we demonstrate that the large language model GPT-4 can accurately annotate cell types using marker gene information in single-cell RNA sequencing analysis. When evaluated across hundreds of tissue and cell types, GPT-4 generates cell type annotations exhibiting strong concordance with manual annotations. This capability can considerably reduce the effort and expertise required for cell type annotation. Additionally, we have developed an R software package GPTCelltype for GPT-4's automated cell type annotation.
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Hou et al. (Mon,) studied this question.
www.synapsesocial.com/papers/68e72644b6db6435876a0154 — DOI: https://doi.org/10.1038/s41592-024-02235-4
Wenpin Hou
Zhicheng Ji
Nature Methods
Columbia University
Duke University
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