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Routine blood tests drive diagnosis, prognosis, and monitoring in traditional clinical decision support systems. As a routine diagnostic tool with standardized laboratory workflows, clinical blood analysis offers superior accessibility to a comprehensive assessment of physiological parameters. These parameters can be integrated and automated at scale, allowing for in-depth clinical inference and cost-effectiveness compared to other modalities such as imaging, genetic testing, or histopathology. Herein, we extensively review the analytical value of routine blood tests leveraged by artificial intelligence (AI), using the ICD-10 classification as a reference. A significant gap exists between standard disease-associated features and those selected by machine learning models. This suggests an amount of non-perceived information in traditional decision support systems that AI could leverage with improved performance metrics. Nonetheless, AI-derived support for clinical decisions must still be harmonized regarding external validation studies, regulatory approvals, and clinical deployment strategies. Still, as we discuss, the path is drawn for the future application of scalable artificial intelligence (AI) to enhance, extract, and classify patterns potentially correlated with pathological states with restricted limitations in terms of bias and representativeness.
Santos-Silva et al. (Mon,) studied this question.