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Four undescribed sesquiterpenoids, lemneolemnanes A–D (1–4), have been isolated from the marine soft coral Lemnalia sp. The absolute configurations of the stereogenic carbons of 1–4 were determined by single-crystal X-ray crystallographic analysis. Compounds 1 and 2 are epimers at C-3 and have an unusual skeleton with a formyl group on C-6. Compound 3 possesses an uncommonly rearranged carbon skeleton, while 4 has a 6/5/5 tricyclic system. Compound 1 showed significant anti-Alzheimer’s disease (AD) activity in a humanized Caenorhabditis elegans AD pathological model.
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Yuan Zong
Tianyun Jin
Junjie Yang
Marine Drugs
University of California, San Diego
Scripps Institution of Oceanography
Chinese Academy of Medical Sciences & Peking Union Medical College
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Zong et al. (Tue,) studied this question.
www.synapsesocial.com/papers/68e7253fb6db64358769ec43 — DOI: https://doi.org/10.3390/md22040145
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