Analysis of Risk Factors for the Association of Sarcopenia in Patients with Type 2 Diabetes Mellitus

Background: Previous studies have shown that the prevalence of sarcopenia in patients with type 2 diabetes mellitus (T2DM) has increased significantly over the years.However, the risk factors for the association of sarcopenia in patients with T2DM are unknown.Therefore, we attempted to investigate the risk factors through measurement and analysis of the patients' data from April 2020 to April 2022.Methods: A total of 334 hospitalized patients with T2DM were divided into sarcopenia group (n=101) and non-sarcopenia group (n=233).Clinical factors were compared between the two groups and also between the two genders.Receiver operating characteristic curve (ROC) was used to analyze the ROC diagnostic ability of related factors in sarcopenia.Results: (1) Among the 334 patients, the overall prevalence of sarcopenia was 30.2%; 41.3% in men and 20.1% in women.(2) The multifactorial logistic regression analysis showed that gender (specifically for men; OR=4.997, 95% CI: 2.611-9.564),low body mass index (BMI) (OR=1.525,95% CI: 1.353-1.718),lower 25(OH)D levels (OR=1.076,95% CI:1.036-1.117),and lower IGF-1 (OR=1.013,95% CI:1.006-1.020)were independent risk factors (P 0.7, has great predictive significance. Conclusion:The prevalence of sarcopenia in hospitalized patients with T2DM is higher in men than in women.Low BMI and lower serum levels of 25 (OH) D and IGF-1 are risk factors of sarcopenia in patients with T2DM.Low BMI, 25(OH)D, IGF-1, and testosterone (for men) all contributed to the prediction of sarcopenia, among which BMI and combined factors were more significant.