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This study was designed to evaluate a six-month variation in CD8, cytotoxic molecules, CD4, viral load, CD4/CD8 ratio, inflammatory cytokines and oxidative stress parameters in chronic HIV infection. A total of 58 HIV sero-positive subjects on HAART were recruited for this study. CDC staging method with CD4 count was used to classify the study subjects. After a baseline sampling, subjects were followed up for 6 months, samples were collected and evaluated every 3 months. The result of the study showed significant (p0.05) difference was seen with GRZM. We observed a significant (p=0.034) variation in IL-10 values for stage I individuals between the baseline and 6-month follow-up. Stage II participants showed a substantial (p0.05) over the course of the 6-month period. Nonetheless, there were notable (p<0.05) variations in TNF-α levels among stage II participants within the follow up period. TAC values for stage I individuals revealed a sizeable (p<0.05) difference between baseline and the 6-month. Likewise, for individuals in stage II, there were notable (p<0.05) modifications in their overall antioxidant capacity between three and six months follow up period. Conclusively, there may be notable changes in the health indices of seropositive individuals in three to six months.
Okparaku et al. (Tue,) studied this question.