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The use of plant-based drugs against various human disorders have attained global interest. Multicomponent essential oils are used to cure inflammation related disorders. The present study was aimed to assess the anti inflammatory potential of essential oil from Rosmarinus officinalis (EO RO) using in vitro model of LPS-activated RAW macrophage cell lines. EO-RO was hydro-distilled using Clevenger apparatus and evaluated first for protein denaturation and proteinase inhibitory activities, followed by assays for cyclooxygenase (COX) and lipoxygenase (LOX) activities in RAW 264.7 macrophage cell lines. The data was statistically analysed by one-way analysis of variance. Dose-dependent inhibition was observed in protein denaturation with 50 µg mL-1 EO-RO exhibiting a maximum inhibition of 67.77%. Similarly, proteinase inhibitory assay depicted 72.47% inhibition. The COX and LOX activities showed increased inhibitions in dose-dependent manner i.e. 25 to 100 µg mL-1 EO-RO displayed 58.72 and 75.33%; 28.58- 40.86% inhibition, respectively.
Kavitha et al. (Sat,) studied this question.