Combination of prostate volume and apparent diffusion coefficient can stratify patients with a PI‐RADS score of 3 to reduce unnecessary prostate biopsies

Abstract Background Nowadays, there are many patients who undergo unnecessary prostate biopsies after receiving a prostate imaging reporting and data system (PI‐RADS) score of 3. Our purpose is to identify cutoff values of the prostate volume (PV) and minimum apparent diffusion coefficient (ADC min ) to stratify those patients to reduce unnecessary prostate biopsies. Methods Data from 224 qualified patients who received prostate biopsies from January 2019 to June 2023 were collected. The Mann–Whitney U test was used to compare non‐normal distributed continuous variables, which were recorded as median (interquartile ranges). The correlation coefficients were calculated using Spearman's rank correlation analysis. Categorical variables are recorded by numbers (percentages) and compared by χ 2 test. Both univariate and multivariate logistic regression analysis were used to determine the independent predictors. The receiver‐operating characteristic curve and the area under the curve (AUC) were used to evaluate the diagnostic performance of clinical variables. Results Out of a total of 224 patients, 36 patients (16.07%) were diagnosed with clinically significant prostate cancer (csPCa), whereas 72 patients (32.14%) were diagnosed with any grade prostate cancer. The result of multivariate analysis demonstrated that the PV ( p < 0.001, odds ratio OR: 0.952, 95% confidence interval 95% CI: 0.927–0.978) and ADC min ( p < 0.01, OR: 0.993, 95% CI: 0.989–0.998) were the independent factors for predicting csPCa. The AUC values of the PV and ADC min were 0.779 (95% CI: 0.718–0.831) and 0.799 (95% CI: 0.740–0.849), respectively, for diagnosing csPCa. After stratifying patients by PV and ADC min , 24 patients (47.06%) with “PV < 55 mL and ADC min < 685 μm 2 /s” were diagnosed with csPCa. However, only one patient (1.25%) with PV ≥ 55 mL and ADC min ≥ 685 μm 2 /s were diagnosed with csPCa. Conclusions In this study, we found the combination of PV and ADC min can stratify patients with a PI‐RADS score of 3 to reduce unnecessary prostate biopsies. These patients with “PV ≥ 55 mL and ADC min ≥ 685 μm 2 /s” may safely avoid prostate biopsies.