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Applying automated segmentation to UK Biobank MRI scans, hypertension, higher body mass index, and higher physical activity levels were associated with increased left ventricle trabeculations in healthy middle-aged White adults.Key Results:1.In a cross-sectional secondary analysis of prospectively collected data from the UK Biobank, applying automated segmentation to cardiac MRI scans, the trabeculated left ventricular (LV) mass was significantly higher in middle-aged White adults with established cardiovascular risk factors (n = 28 672) compared with a healthy reference group (n = 7384) for both men (median (IQR) of 6.8 g (5.1, 9.0) vs. 6.3 g (4.7, 8.5), P<.001) and women (5.1g (3.8, 6.7) vs. 4.6 g ( 3.4, 6.0) P<.001).2. Hypertension (β=0.42,95% CI: 0.36, 0.48, P<.001), higher body mass index (β=0.66,95% CI: 0.63, 0.68, P<.001), and higher physical activity levels (β=0.15,95% CI: 0.12, 0.17, P<.001), were associated with increased LV trabeculation.3. Age-and sex-specific reference ranges of trabeculated LV mass values in a middle-aged healthy White population were established.
Aung et al. (Mon,) studied this question.