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Abstract A dinuclear metal‐organic cage with four acrylate side chains was prepared by self‐assembly. Precipitation polymerization of the cage with N‐isopropylacrylamide yielded a thermoresponsive nanogel. The host properties of the cage were retained within the gel matrix, endowing the nanogel with the capability to serve as a sorbent for chloride ions in water. Moreover, a heteroleptic cage with the drug abiraterone as co‐ligand was integrated into a nanogel. The addition of chloride ions induced a structural rearrangement of the metal‐ligand assembly, resulting in the gradual release of abiraterone.
Hu et al. (Fri,) studied this question.