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Reducing the levels of triglycerides and triglyceride-rich lipoproteins remains an unmet clinical need. Olezarsen is an antisense oligonucleotide targeting messenger RNA for apolipoprotein C-III (APOC3), a genetically validated target for triglyceride lowering.
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Brian A. Bergmark
Nicholas Marston
Thomas A Prohaska
New England Journal of Medicine
Brigham and Women's Hospital
Ionis Pharmaceuticals (United States)
Thrombolysis in Myocardial Infarction Study Group
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Bergmark et al. (Sun,) studied this question.
www.synapsesocial.com/papers/68e700f4b6db64358767b7c6 — DOI: https://doi.org/10.1056/nejmoa2402309
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