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Increased fluid viscosity in vivo is associated with diseases such as hypertension, atherosclerosis, and cancer. Fortunately, viscosity distribution enables pathological diagnosis. Magnetic-particle imaging (MPI), which detects the high-frequency magnetic field response of magnetic nanoparticles (MNPs) for obtaining highly sensitive images, can be applied to viscosity mapping to obtain a solvent viscosity distribution based on the relaxation time of MNPs. In this study, we assessed the relaxation time differences of MNPs in media with varying viscosities, detected as phase differences in the signal using an MPI system. The differences, which increases with more viscosity, differ depending on the particle size and the magnetic properties of the magnetic nanoparticles.
Washino et al. (Mon,) studied this question.