Skin Grafting for Dermatologists: Past, Present, and Future

Abstract Purpose of This Review Skin grafting is a surgical procedure that involves replacing damaged or missing skin with healthy skin. This technique helps protect wounds, promotes healing, and enhances functionality and appearance. Skin grafting can be beneficial in treating burns, traumatic injuries, chronic ulcers, surgical wounds, and congenital defects, among others. Recent Findings A range of cellular and tissue-based products (CTPs) can be employed, either in conjunction with autologous skin grafts or independently, to facilitate wound healing. Human skin allografts, sourced from donated human skin, often obtained from cadavers, serve as a valuable resource for wound protection. Allogeneic matrices, comprising neonatal fibroblasts or membranes, alongside chorion, amnion, and other placental products, provide a means to accelerate the wound healing process. Composite matrices, which combine human keratinocytes, fibroblasts, and xenogeneic collagen, provide a solution to replicate the complexity of natural skin. Moreover, acellular matrices derived from xenogeneic collagen or tissue offer a versatile platform for tissue regeneration. Conclusion Skin grafting is a complex procedure that requires careful planning and postoperative care. Success depends on factors like the type of graft, wound management, and overall health of the patient. Skin grafting has evolved with advancements in surgery, anesthesia, and wound care and remains a crucial technique for restoring function and appearance.