Diagnosis and treatment of a case of eosinophilic solid cystic renal cell carcinoma and review of the literature

Eosinophilic solid and cystic renal cell carcinoma (ESC RCC) is a relatively rare kidney tumor subtype, first documented pathologically by Trpkov et al. in 2016[1](#ref-0001).Although first described and named in pathology literature, ESC RCC is not included in the 2016 World Health Organization (WHO) classification. However, the Genitourinary Pathology Society recommended it in 2021 as a new renal cell carcinoma entity[2](#ref-0002).Owing to its low incidence and relative rarity, as well as a general lack of familiarity among pathologists, ESC RCC can easily be confused with other renal tumors bearing similar morphological characteristics.In this article, we will summarize and analyze clinicopathology, clinical manifestations, imaging, and differential diagnosis of ESC RCC. We will draw insights from a recently diagnosed ESC RCC patient at our hospital and study relevant literature from both domestic and international sources. Our goal is to enhance the diagnosis and comprehension of ESC RCC among medical professionals and provide a deeper understanding of this rare subtype.