Origin of functional de novo genes in humans from “hopeful monsters”

Abstract For a long time, it was believed that new genes arise only from modifications of preexisting genes, but the discovery of de novo protein‐coding genes that originated from noncoding DNA regions demonstrates the existence of a “motherless” origination process for new genes. However, the features, distributions, expression profiles, and origin modes of these genes in humans seem to support the notion that their origin is not a purely “motherless” process; rather, these genes arise preferentially from genomic regions encoding preexisting precursors with gene‐like features. In such a case, the gene loci are typically not brand new. In this short review, we will summarize the definition and features of human de novo genes and clarify their process of origination from ancestral non‐coding genomic regions. In addition, we define the favored precursors, or “hopeful monsters,” for the origin of de novo genes and present a discussion of the functional significance of these young genes in brain development and tumorigenesis in humans. This article is categorized under: RNA Evolution and Genomics > RNA and Ribonucleoprotein Evolution