Pd29-06 Mental Wellbeing in Prostate Cancer: Results From the Multi-Centre Mind-P Cohort Study

You have accessJournal of UrologyProstate Cancer: Epidemiology & Natural History I (PD29)1 May 2024PD29-06 MENTAL WELLBEING IN PROSTATE CANCER: RESULTS FROM THE MULTI-CENTRE MIND-P COHORT STUDY Oliver Brunckhorst, Jaroslaw Liszka, Callum James, Jack Fanshawe, Mohamed Hammadeh, Robert Thomas, Shahid Khan, Matin Sheriff, Hashim Ahmed, Gordon Muir, Mieke Van Hemelrijck, Robert Stewart, Prokar Dasgupta, and Kamran Ahmed Oliver BrunckhorstOliver Brunckhorst , Jaroslaw LiszkaJaroslaw Liszka , Callum JamesCallum James , Jack FanshaweJack Fanshawe , Mohamed HammadehMohamed Hammadeh , Robert ThomasRobert Thomas , Shahid KhanShahid Khan , Matin SheriffMatin Sheriff , Hashim AhmedHashim Ahmed , Gordon MuirGordon Muir , Mieke Van HemelrijckMieke Van Hemelrijck , Robert StewartRobert Stewart , Prokar DasguptaProkar Dasgupta , and Kamran AhmedKamran Ahmed View All Author Informationhttps://doi.org/10.1097/01.JU.0001008736.23117.7f.06AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: There is increasing evidence to demonstrate the mental wellbeing impact of prostate cancer. However, prognostic factors for these outcomes are less understood. This study therefore aimed to investigate the patient, treatment, and oncological factors associated with multiple mental wellbeing outcomes in prostate cancer. METHODS: A prospective and multi-centre cohort study was conducted across 8 UK sites (NCT04647474). Newly diagnosed patients were recruited for 12 months post diagnosis with 3-monthly questionnaires conducted evaluating mental, physical, and social wellbeing outcomes. Five outcomes of interest (depression, anxiety, fear of recurrence, body image issues, and masculine self-esteem) were selected based on background literature and qualitative patient data. Cumulative incidence of significant wellbeing issues was calculated, with ANOVA utilised to evaluate symptoms scores between different management cohorts. Subsequent multivariate regression was conducted exploring other baseline patient and oncological factors against each outcome. RESULTS: 300 newly diagnosed prostate cancer patients were recruited. During follow up 13.7% and 11.0% developed significant depression or anxiety symptoms. Overall, 45.0% of patients developed at least one significant mental wellbeing issue. The hormone monotherapy group demonstrated higher depression scores from 6 months post diagnosis (all p<0.05). Those who underwent prostatectomy subsequently demonstrated poorer body image and masculine self-esteem scores from 3 months, particularly compared to active surveillance patients (all p<0.02). Metastatic stage at diagnosis was associated with increased depression (aOR 4.09 p=0.01), anxiety (aOR 3.58, p=0.03) and fear of cancer recurrence (aOR 2.98, p=0.01). When considering patient factors, outcomes were poorer for those who were younger age (aOR 0.95-0.99), had a previous mental health diagnosis (aOR 3.00-3.89), increased social deprivation, and those with poorer baseline sexual and urinary function (all outcomes p<0.01). Little relationship was evident between ethnicity, marital status, employment status, and other co-morbidities. CONCLUSIONS: We confirm the significant burden of mental wellbeing issues within the early prostate cancer period highlighting their importance. Predictive features included younger age, advanced disease, baseline mental wellbeing, and baseline functional status which should be considered when considering patients who should have increased surveillance during their follow up care. Source of Funding: King's Medical Research Trust © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e620 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Oliver Brunckhorst More articles by this author Jaroslaw Liszka More articles by this author Callum James More articles by this author Jack Fanshawe More articles by this author Mohamed Hammadeh More articles by this author Robert Thomas More articles by this author Shahid Khan More articles by this author Matin Sheriff More articles by this author Hashim Ahmed More articles by this author Gordon Muir More articles by this author Mieke Van Hemelrijck More articles by this author Robert Stewart More articles by this author Prokar Dasgupta More articles by this author Kamran Ahmed More articles by this author Expand All Advertisement PDF downloadLoading ...