Mp35-07 Racial Differences in Bladder Cancer Mortality Adjusting for Sociodemographic Disparities in a Statewide Cancer Registry

You have accessJournal of UrologyBladder Cancer: Epidemiology & Evaluation II (MP35) 1 May 2024MP35-07 RACIAL DIFFERENCES IN BLADDER CANCER MORTALITY ADJUSTING FOR SOCIODEMOGRAPHIC DISPARITIES IN A STATEWIDE CANCER REGISTRY Mollie Goldman, Camilo Arenas-Gallo, Adithya Balasubramanian, Jack Millot, Xian Wu, Alec Zhu, Stephen Rhodes, Jason Brown, and Jonathan E. Shoag Mollie GoldmanMollie Goldman, Camilo Arenas-GalloCamilo Arenas-Gallo, Adithya BalasubramanianAdithya Balasubramanian, Jack MillotJack Millot, Xian WuXian Wu, Alec ZhuAlec Zhu, Stephen RhodesStephen Rhodes, Jason BrownJason Brown, and Jonathan E. ShoagJonathan E. Shoag View All Author Informationhttps: //doi. org/10. 1097/01. JU. 0001009372. 61513. 54. 07AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Sociodemographic disparities influence bladder cancer (BCa) outcomes. We explored differences in bladder cancer specific mortality (BCSM) and other-cause mortality (OCM) between Black and White patients from Ohio, after accounting for baseline characteristics, cancer features, and social determinants of health including area deprivation index (ADI) and wealth. METHODS: We used the Ohio Cancer Incidence Surveillance System to capture clinical and demographic data from patients diagnosed with BCa between 1996 to 2016. Patient home addresses were linked to home value estimates from Zillow. com to serve as a proxy for individual wealth (Zestimate). ADI was sourced at the census block group level. Primary outcomes were group differences in BCSM and OCM. Groups were balanced for cancer and sociodemographic variables at diagnosis via inverse probability weighting. Group comparisons were made via weighted cumulative incidence functions and weighted Fine-Grey subdistribution hazard models. RESULTS: The final cohort included 37, 148 patients, of which 35, 182 (95%) were White and 1, 966 (5%) were Black. Most patients had urothelial BCa (94. 3%) and in situ or localized disease (81. 4%). White patients had higher mean Zestimate (227, 530±145, 083) compared to Black patients (150, 417±97, 750, p<0. 001). Black patients had higher ADI, indicating greater deprivation (Black=116. 2±20. 6, White=95. 4±17. 0, p<0. 001) (Table 1). After adjustments for ADI and tumor characteristics, Black patients experienced a 3. 8% increased 10-year BCSM (95%CI: 0. 5–7. 2%) and a 5. 2% decreased OCM (CI: -9. 3–-1. 0%) compared to White patients. When including Zestimates in the analysis, Black patients still had 3. 6% increased BCSM (CI: 0. 1–7. 1%) and 7. 1% decreased OCM (CI: -11. 3–-2. 9%) relative to White patients (Figure 1). All-cause mortality for Black patients was not different from White after adjusting for all variables (HR: 1. 01 95%CI: 0. 91-1. 12 p=0. 9). CONCLUSIONS: Even after adjusting for clinical and socioeconomic factors, Black patients demonstrated worse BCSM outcomes without differences in all-cause mortality than White patients suggesting persistence of unmeasured barriers in cancer treatment access. Download PPT Source of Funding: The work presented here was not directly funded by an outside organization or sponsor. JES is supported by the Frederick J. and Theresa Dow Fund of the New York Community Trust, the Vinney Scholars Award, and a Damon Runyon Cancer Research Foundation Physician Scientist Training Award © 2024 by American Urological Association Education and Research, Inc. FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e583 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc. Metrics Author Information Mollie Goldman More articles by this author Camilo Arenas-Gallo More articles by this author Adithya Balasubramanian More articles by this author Jack Millot More articles by this author Xian Wu More articles by this author Alec Zhu More articles by this author Stephen Rhodes More articles by this author Jason Brown More articles by this author Jonathan E. Shoag More articles by this author Expand All Advertisement PDF downloadLoading. . .