Mp49-15 Evaluating the Role of Pri-Mus Protocol in Identifying Clinically Significant Prostate Cancer: A High-Volume Experience on Microultrasound

You have accessJournal of UrologyProstate Cancer: Detection csPCa) was determined and the diagnostic performance of mUS was assessed. Logistic regression models (LRMs) were fitted to test the predictors of csPCa. RESULTS: Mean age was 66(IQR 60-72) yrs, median total PSA was 7.0(IQR 5-9.8) ng/mL and median prostate volume was 50(IQR 38-65) mL. Overall, 38.3% patients were in the repeat biopsy setting, with 15.3% patients on active surveillance. MUS detected prostate lesions with a PRI-MUS score of 3, 4 and 5 in respectively 128 (9.1%), 622 (44.2%) and 281(20.0%) patients, while in 363(25.8%) individuals mUS did not identify any target. Overall PCa and csPca detection rates were 51.6%(724/1404) and 37.0%(519/1406). Micro-US provided high sensitivity, with 88.2% (458/519) of csPCa patients having at least one PRI-mMUS score ≥3 lesion. Similarly, NPV was 83.0% with 297/358 patients with no micro-US targets receiving a benign or insignificant PCa diagnosis (after systematic and MRI-target biopsy). Conversely, PPV and specificity were lower (43.8% and 33.6%), likely due to over-targeting. CsPCa rate according to PRI-MUS score was in 24.7% (34/137) for PRI-MUS 3, 37.7% (237/628) for PRI-MUS 4 and 66.5% (187/281) for PRI-MUS 5. The ratio between csPCa and overall PCa diagnosed increased with increasing PRIMUS score (58.6%, 68.5% and 92.6% for PRIMUS 3, 4 and 5 lesions). CONCLUSIONS: Our results the accuracy of PRI-MUS protocol in risk stratifying patients undergoing prostate biopsy and differentiate between non-significant and csPCa. MicroUS is a fast and efficient modality for PCa evalution, with high sensitivity and negative predictive value for csPCa as well as allowing lesion identification and targeting. Source of Funding: None © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e788 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Davide Maffei More articles by this author Pier Paolo Avolio More articles by this author Stefano Moretto More articles by this author Andrea Piccolini More articles by this author Muhannad Aljoulani More articles by this author Filippo Dagnino More articles by this author Fabio De Carne More articles by this author Vittorio Fasulo More articles by this author Paciotti Marco More articles by this author Alberto Rosario Saita More articles by this author Rodolfo Fausto Hurle More articles by this author Giorgio Ferruccio Guazzoni More articles by this author Paolo Casale More articles by this author Nicolò Maria Buffi More articles by this author Massimo Lazzeri More articles by this author Giovanni Lughezzani More articles by this author Expand All Advertisement PDF downloadLoading ...