Mp30-01 a New Look: The Promising Use of 3-Dimensional Quantitative Transmission Ultrasound Tomography for the Detection of Prostate Cancer an Ex Vivo Study

You have accessJournal of UrologyImaging/Uroradiology II (MP30)1 May 2024MP30-01 A NEW LOOK: THE PROMISING USE OF 3-DIMENSIONAL QUANTITATIVE TRANSMISSION ULTRASOUND TOMOGRAPHY FOR THE DETECTION OF PROSTATE CANCER AN EX VIVO STUDY Sahil H. Parikh, Charles Hesswani, William S. Azar, Christopher R. Koller, Kyle C. Schuppe, Alexander P. Kenigsberg, Neil Mendhiratta, Sarah Azari, Daniel Nethala, Yixuan Wu, James Wiskin, Emad Boctor, John Klock, Bradford Wood, Sandeep Gurram, Baris Turkbey, and Peter A. Pinto Sahil H. ParikhSahil H. Parikh , Charles HesswaniCharles Hesswani , William S. AzarWilliam S. Azar , Christopher R. KollerChristopher R. Koller , Kyle C. SchuppeKyle C. Schuppe , Alexander P. KenigsbergAlexander P. Kenigsberg , Neil MendhirattaNeil Mendhiratta , Sarah AzariSarah Azari , Daniel NethalaDaniel Nethala , Yixuan WuYixuan Wu , James WiskinJames Wiskin , Emad BoctorEmad Boctor , John KlockJohn Klock , Bradford WoodBradford Wood , Sandeep GurramSandeep Gurram , Baris TurkbeyBaris Turkbey , and Peter A. PintoPeter A. Pinto View All Author Informationhttps://doi.org/10.1097/01.JU.0001009416.90901.7b.01AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Quantitative Transmission ultrasound tomography (UT) is an ultrasound modality that can generate 3-demensional (3D) volumetric measurements. It is FDA approved for use in breast imaging. Its role in prostate imaging as an alternative to multiparametric MRI (mpMRI) remains under investigation. Currently mpMRI is the preferred imaging modality for detecting prostate cancer (PCa), however universal adoptions have been limited due to various logistical constraints. The purpose of this study is to validate the use of UT in detecting PCa by imaging ex vivo whole prostate specimens after radical prostatectomy (RP). METHODS: Patients with biopsy proven PCa underwent RP immediately followed by UT (QT Imaging Inc, Novato, CA). Tumor boundaries on UT were read and segmented by an expert genitourinary radiologist with >15-year experience reading images of various modalities. UT images were annotated by the radiologist blinded to final pathology results and correlated to wholemount pathology slides used as gold standard. These pathology slides were annotated blinded by experienced genitourinary pathologists. Sensitivity, specificity, and accuracy were calculated for UT as compared to final pathology wholemounts. RESULTS: From April 2021-March 2022, we identified 25 patients who underwent RP, had their prostate scanned ex vivo with UT, and underwent wholemount prostate specimen annotations (Figure 1). The median age at RP was 61 years (IQR 59-71). 1 patient had grade group (GG) 1 (4%) on RP, 9 had GG2 (36%), 6 had GG3 (24%), 3 had GG4 (12%) and 6 had GG5 (24%). The median number of lesions identified on UT was 2 (IQR 1-2). UT was able to identify every index lesion for all patients scanned. On comparative analysis, UT showed a specificity of 84%, a sensitivity of 54%, and an accuracy of 70% to detect clinically significant PCa. CONCLUSIONS: Prostate 3D UT is a promising technology that is able to detect clinically significant PCa ex vivo. Its advantages include a fast image acquisition time (15 minutes), lack of contrast, and potential for a future in office base platform. Although it presents a promising device to detect PCa, device development is warranted to validate it in vivo. Download PPT Source of Funding: N/A © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e490 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Sahil H. Parikh More articles by this author Charles Hesswani More articles by this author William S. Azar More articles by this author Christopher R. Koller More articles by this author Kyle C. Schuppe More articles by this author Alexander P. Kenigsberg More articles by this author Neil Mendhiratta More articles by this author Sarah Azari More articles by this author Daniel Nethala More articles by this author Yixuan Wu More articles by this author James Wiskin More articles by this author Emad Boctor More articles by this author John Klock More articles by this author Bradford Wood More articles by this author Sandeep Gurram More articles by this author Baris Turkbey More articles by this author Peter A. Pinto More articles by this author Expand All Advertisement PDF downloadLoading ...