Pd43-10 Age-Related Trends in Prevalence and Quality of Life Impact of Lower Urinary Tract Symptoms Among Women With and Without Overactive Bladder

You have accessJournal of UrologyUrodynamics/Lower Urinary Tract Dysfunction/Female Pelvic Medicine: Overactive Bladder I (PD43)1 May 2024PD43-10 AGE-RELATED TRENDS IN PREVALENCE AND QUALITY OF LIFE IMPACT OF LOWER URINARY TRACT SYMPTOMS AMONG WOMEN WITH AND WITHOUT OVERACTIVE BLADDER Kyle B. Zuniga, Crystal Cisneros, Emma Dixon, and Anne L. Ackerman Kyle B. ZunigaKyle B. Zuniga , Crystal CisnerosCrystal Cisneros , Emma DixonEmma Dixon , and Anne L. AckermanAnne L. Ackerman View All Author Informationhttps://doi.org/10.1097/01.JU.0001009568.19060.25.10AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Little is known regarding age-related trends in prevalence and quality of life (QOL) impact of lower urinary tract symptoms (LUTS) among women with and without urinary urgency, the hallmark of overactive bladder (OAB). Objective: To examine the prevalence of LUTS among women with and without OAB and to explore the impact on QOL of these concomitant LUTS among age groups. METHODS: A nationally representative cross-sectional survey of U.S. adults obtained using the online research platform, Prolific, examined the prevalence of and bother from a wide range of genitourinary symptoms using validated questionnaires, including the International Consultation on Incontinence Modular Questionnaire on Female LUTS (ICIQ-fLUTS) and the Genitourinary Pain Index (GUPI). Subjects were stratified into four age quartiles: 18-30, 31-45, 45-59, and 60+. Differences in prevalence and symptom scores were explored using chi-squared tests and ANOVA as appropriate. The effect of LUTS on GUPI bother score was then examined using multivariable linear regression. RESULTS: 790 women were included. Average age was 45+16 (range 18-93). There was a statistically significant increase in the rates of nocturia, urgency, and incontinence and a decrease in the rate of frequency with each age quartile. 211 (27%) women reported significant urinary urgency, defined as OAB. OAB was more common among older women (30% of 60+) than in younger women (20% of 18-30, p<0.01). Compared to women without OAB, a statistically significantly higher proportion of women with OAB endorsed having all other LUTS queried in the ICIQ, with frequency (83% vs. 68%, p<0.01), nocturia (54% vs. 26%, p<0.01), and stress incontinence (50% vs. 14%, p<0.01) being the most common. Among women with OAB, prevalence of concomitant LUTS was similar among age quartiles. Incontinence and pain conferred the greatest magnitude of bother. Younger women tended to have a greater negative QOL impact from a broader variety of LUTS (e.g., nocturia, urgency, incontinence), while pain tended to be the only symptom with a major impact on QOL among older women. CONCLUSIONS: Concomitant LUTS were common among women with OAB compared to women without OAB, suggesting urgency is a harbinger of global voiding dysfunction. Additionally, degree of bother from LUTS was worse among younger patients, suggesting a different degree of distress and expectations between age groups. Querying the degree of bother from and providing treatment for concomitant LUTS among women with OAB is essential for the provision of high-quality care. Source of Funding: UCLA H & H Lee Surgical Research Scholars Program © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e902 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Kyle B. Zuniga More articles by this author Crystal Cisneros More articles by this author Emma Dixon More articles by this author Anne L. Ackerman More articles by this author Expand All Advertisement PDF downloadLoading ...