Mp16-11 Long-Term Outcomes of Pta High Grade Intermediate and High Risk Bladder Cancer Patients

You have accessJournal of UrologyBladder Cancer: Non-invasive I (MP16)1 May 2024MP16-11 LONG-TERM OUTCOMES OF PTA HIGH GRADE INTERMEDIATE AND HIGH RISK BLADDER CANCER PATIENTS Pietro Scilipoti, Leonardo Quarta, Mattia Longoni, Mario De Angelis, Chiara Re, Giuseppe Basile, Giulio Avesani, Alessandro Bertini, Giusy Burgio, Francesco Pellegrino, Giuseppe Rosiello, Andrea Necchi, Daniele Raggi, Roberta Lucianò, Renzo Colombo, Giorgio Gandaglia, Umberto Capitanio, Andrea Salonia, Francesco Montorsi, Alberto Briganti, and Marco Moschini Pietro ScilipotiPietro Scilipoti , Leonardo QuartaLeonardo Quarta , Mattia LongoniMattia Longoni , Mario De AngelisMario De Angelis , Chiara ReChiara Re , Giuseppe BasileGiuseppe Basile , Giulio AvesaniGiulio Avesani , Alessandro BertiniAlessandro Bertini , Giusy BurgioGiusy Burgio , Francesco PellegrinoFrancesco Pellegrino , Giuseppe RosielloGiuseppe Rosiello , Andrea NecchiAndrea Necchi , Daniele RaggiDaniele Raggi , Roberta LucianòRoberta Lucianò , Renzo ColomboRenzo Colombo , Giorgio GandagliaGiorgio Gandaglia , Umberto CapitanioUmberto Capitanio , Andrea SaloniaAndrea Salonia , Francesco MontorsiFrancesco Montorsi , Alberto BrigantiAlberto Briganti , and Marco MoschiniMarco Moschini View All Author Informationhttps://doi.org/10.1097/01.JU.0001008640.01272.9d.11AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: European association of urology (EAU) prognostic risk models have been implemented to guide treatment selection in non-muscle invasive bladder cancer patients (NMIBC). We hypothesized that patients harbouring pTa high grade have different survival outcomes compared to other intermediate or high-risk patients. METHODS: We conducted a retrospective analysis including 397 IR- and HR- NMIBC patients treated with BCG immunotherapy accordingly to risk classification from 2010 to 2022 at a single tertiary referral center. Kaplan-Meier curves were used to estimate the 4-year recurrence-free survival (RFS) and progression-free survival (PFS) among groups and compared using long-rank test. Multivariable Cox and logistic regression analysis (MVA) were used to identify predictors of progression and BCG-failure, adjusting for adequate BCG treatment and presence of carcinoma in situ. RESULTS: Overall, we identified 199 HR and 198 IR patients. Of 201 TaHG NMIBC, 87 (43%) and 114 (57%) had IR and HR. After a median follow up of 44 (IQR 28-56) months, we observed 117 recurrences, 52 progressions and 88 BCG-failures. IR-TaHG and HR-TaHG had similar 4-years RFS compared to IR-Ta/T1LG tumors and HR-T1/HG tumors (68% HR-TaHG vs 71% IR-TaHG vs 70% IR-Ta/T1HG vs 71% HR-T1HG, all p>0.05). Patients with IR-TaHG and HR-TaHG had lower estimated PFS compared to IR-Ta/T1LG group, but higher than HR-T1/HG tumors (87% HR-TaHG vs 86% IR-TaHG vs 95% IR-Ta/T1HG vs 77% HR-T1HG) (Figure 1, all p<0.05). At MVA, both IR-TaHG (HR 2.28, 95%CI 1.36-3.84, p=0.002) and HR-TaHG (HR 2.13, 95%CI 1.21-2.77, p=0.034 ) were predictors of progression, while having a higher risk of BCG failure IR-TaHG: (OR 3.23, 95%CI 1.35-8.23, p=0.01) and [HR-TaHG: (OR 3.59, CI 1.45-9.37, p=0.007) compared to IR-Ta/T1LG patients. CONCLUSIONS: Among IR and HR NMIBC, patients with TaHG disease exhibited comparable risks of progression and BCG failure, regardless of their risk class stratification. Download PPT Source of Funding: None © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e244 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Pietro Scilipoti More articles by this author Leonardo Quarta More articles by this author Mattia Longoni More articles by this author Mario De Angelis More articles by this author Chiara Re More articles by this author Giuseppe Basile More articles by this author Giulio Avesani More articles by this author Alessandro Bertini More articles by this author Giusy Burgio More articles by this author Francesco Pellegrino More articles by this author Giuseppe Rosiello More articles by this author Andrea Necchi More articles by this author Daniele Raggi More articles by this author Roberta Lucianò More articles by this author Renzo Colombo More articles by this author Giorgio Gandaglia More articles by this author Umberto Capitanio More articles by this author Andrea Salonia More articles by this author Francesco Montorsi More articles by this author Alberto Briganti More articles by this author Marco Moschini More articles by this author Expand All Advertisement PDF downloadLoading ...