Mp08-11 Impact of Pre-Surgery Egfr and Her2 Plasma Levels on Post-Surgical Outcomes in Bladder Cancer Patients Receiving Radical Cystectomy

You have accessJournal of UrologyBladder Cancer: Epidemiology & Evaluation I (MP08)1 May 2024MP08-11 IMPACT OF PRE-SURGERY EGFR AND HER2 PLASMA LEVELS ON POST-SURGICAL OUTCOMES IN BLADDER CANCER PATIENTS RECEIVING RADICAL CYSTECTOMY Katharina Oberneder, Jakob Klemm, Victor M. Schuettfort, Ekaterina Laukhtina, Mehdi Kardoust Parizi, Jeremy Yuen-Chun Teoh, Mohammad Abufaraj, Marek Babjuk, Akihiro Matsukawa, Marco Moschini, Francesco Soria, Paolo Gontero, Pierre Karakiewicz, Eva Compérat, Dmitry V. Enikeev, and Shahrokh F. Shariat Katharina ObernederKatharina Oberneder , Jakob KlemmJakob Klemm , Victor M. SchuettfortVictor M. Schuettfort , Ekaterina LaukhtinaEkaterina Laukhtina , Mehdi Kardoust PariziMehdi Kardoust Parizi , Jeremy Yuen-Chun TeohJeremy Yuen-Chun Teoh , Mohammad AbufarajMohammad Abufaraj , Marek BabjukMarek Babjuk , Akihiro MatsukawaAkihiro Matsukawa , Marco MoschiniMarco Moschini , Francesco SoriaFrancesco Soria , Paolo GonteroPaolo Gontero , Pierre KarakiewiczPierre Karakiewicz , Eva CompératEva Compérat , Dmitry V. EnikeevDmitry V. Enikeev , and Shahrokh F. ShariatShahrokh F. Shariat View All Author Informationhttps://doi.org/10.1097/01.JU.0001008780.87855.57.11AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Outcomes after Neoadjuvant Chemotherapy and Radical Cystectomy (RC) for Urothelial Carcinoma of the Bladder (UCB) are variable. Current biomarkers have limitations in predicting disease course and treatment efficacy. This study assesses the predictive value of preoperative Human Epidermal Growth Factor Receptor 2 (HER2) and Epidermal Growth Factor Receptor (EGFR) plasma levels, biomarkers associated with oncological outcomes in other malignancies. We propose both biomarkers correlate with oncological outcomes. METHODS: In this retrospective study, we included 1,036 patients who underwent RC for non-metastatic UCB at two medical institutions. On the morning of the surgery, quantitative analyses of preoperative EGFR and HER2 plasma levels were performed. Clinical follow-up included urine cytology, and imaging. Recurrence-free survival (RFS), cancer-specific survival (CSS), and overall survival (OS) were subsequently evaluated for all patients. Statistics included multivariable regression models, Receiver operating characteristic-curve analyses and Harrel's C-index. RESULTS: When stratified by median plasma levels, patients with high EGFR (>2.87 μg/dL, N=519) and HER2 levels (>10.5 ng/ml, N=541) showed a greater prevalence of advanced pT stage, high grade disease, lymphovascular invasion, and lymph node involvement compared to those with low EGFR (<2.87 μg/dL, N=517) and HER2 (<10.5 ng/ml, N=495) levels. Multivariable logistic regression models showed significant associations of EGFR and HER2 with lymph node involvement, pT3/4 disease, and any non-organ confined disease (all p<0.05). In multivariable Cox regression models adjusting for established pretreatment clinical parameters, both EGFR and HER2 were significantly associated with survival outcomes. The C-index improved when EGFR and HER2 were incorporated. Post-treatment models further supported these findings, indicating a significant correlation of these biomarkers with oncological outcomes and an enhanced C-index. CONCLUSIONS: EGFR and HER2 plasma levels are associated with RFS, CSS, and OS. With further validation, they could be integrated into clinical practices, refining treatment predictions and optimizing patient treatment selection. Source of Funding: None © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e118 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Katharina Oberneder More articles by this author Jakob Klemm More articles by this author Victor M. Schuettfort More articles by this author Ekaterina Laukhtina More articles by this author Mehdi Kardoust Parizi More articles by this author Jeremy Yuen-Chun Teoh More articles by this author Mohammad Abufaraj More articles by this author Marek Babjuk More articles by this author Akihiro Matsukawa More articles by this author Marco Moschini More articles by this author Francesco Soria More articles by this author Paolo Gontero More articles by this author Pierre Karakiewicz More articles by this author Eva Compérat More articles by this author Dmitry V. Enikeev More articles by this author Shahrokh F. Shariat More articles by this author Expand All Advertisement PDF downloadLoading ...