Mp22-07 Contemporary Conditional Cancer-Specific Survival Rates in Surgically Treated Non-Metastatic Primary Urethral Carcinoma

You have accessJournal of UrologyBladder Cancer: Invasive II (MP22)1 May 2024MP22-07 CONTEMPORARY CONDITIONAL CANCER-SPECIFIC SURVIVAL RATES IN SURGICALLY TREATED NON-METASTATIC PRIMARY URETHRAL CARCINOMA Simone Morra, Lukas Scheipner, Andrea Baudo, Letizia M. I. Jannello, Mario De Angelis, Carolin Siech, Jordan A. Goyal, Nawar Touma, Zhe Tian, Fred Saad, Sharhokh Shariat, Massimiliano Creta, Gianluigi Califano, Giuseppe Celentano, Claudia Colla' Ruvolo, Sascha Ahyai, Luca Carmignani, Ottavio De Cobelli, Gennaro Musi, Alberto Briganti, Felix K. H. Chun, Nicola Longo, and Pierre I. Karakiewicz Simone MorraSimone Morra , Lukas ScheipnerLukas Scheipner , Andrea BaudoAndrea Baudo , Letizia M. I. JannelloLetizia M. I. Jannello , Mario De AngelisMario De Angelis , Carolin SiechCarolin Siech , Jordan A. GoyalJordan A. Goyal , Nawar ToumaNawar Touma , Zhe TianZhe Tian , Fred SaadFred Saad , Sharhokh ShariatSharhokh Shariat , Massimiliano CretaMassimiliano Creta , Gianluigi CalifanoGianluigi Califano , Giuseppe CelentanoGiuseppe Celentano , Claudia Colla' RuvoloClaudia Colla' Ruvolo , Sascha AhyaiSascha Ahyai , Luca CarmignaniLuca Carmignani , Ottavio De CobelliOttavio De Cobelli , Gennaro MusiGennaro Musi , Alberto BrigantiAlberto Briganti , Felix K. H. ChunFelix K. H. Chun , Nicola LongoNicola Longo , and Pierre I. KarakiewiczPierre I. Karakiewicz View All Author Informationhttps://doi.org/10.1097/01.JU.0001008608.50694.4b.07AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: We examined the effect of disease-free interval (DFI) duration on cancer-specific mortality (CSM)-free survival, otherwise known as the effect of conditional survival, in radical urethrectomy non-metastatic primary urethral carcinoma (PUC) patients. METHODS: Using the Surveillance, Epidemiology, and End Results (SEER) database 2000-2020, patient (age, sex, race/ethnicity, marital status) and tumor (stage, histology) characteristics, as well as systemic therapy exposure status of non-metastatic PUC patients were tabulated. Conditional survival estimates at 5-year were assessed based on DFI duration and according to stage at presentation (T1-2N0 vs T3-4N0-2). RESULTS: Of all 512 radical urethrectomy PUC patients, 278 (54%) harbored T1-2N0 stage vs 234 (46%) harbored T3-4N0-2 stage. In 512 PUC patients, 5-year CSM-free survival at initial diagnosis was 61.8%. Provided a DFI duration of 36 months, 5-year CSM-free survival was 85.6%. In 278 T1-2N0 PUC patients, 5-year CSM-free survival at initial diagnosis was 68.4%. Provided a DFI duration of 36 months, 5-year CSM-free survival was 86.9%In 234 T3-4N0-2 PUC patients, 5-year CSM-free survival at initial diagnosis was 53.8%. Provided a DFI duration of 36 months, 5-year CSM-free survival was 83.6%. CONCLUSIONS: Although intuitively, clinicians and patients are well aware of the concept that increasing DFI duration improves survival probability, only a few clinicians can accurately estimate the magnitude of survival improvement, as was done within the current study. Such information is crucial to survivors, especially in those diagnosed with rare malignancies, where the survival estimation according to DFI duration is even more challenging. Source of Funding: None © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e343 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Simone Morra More articles by this author Lukas Scheipner More articles by this author Andrea Baudo More articles by this author Letizia M. I. Jannello More articles by this author Mario De Angelis More articles by this author Carolin Siech More articles by this author Jordan A. Goyal More articles by this author Nawar Touma More articles by this author Zhe Tian More articles by this author Fred Saad More articles by this author Sharhokh Shariat More articles by this author Massimiliano Creta More articles by this author Gianluigi Califano More articles by this author Giuseppe Celentano More articles by this author Claudia Colla' Ruvolo More articles by this author Sascha Ahyai More articles by this author Luca Carmignani More articles by this author Ottavio De Cobelli More articles by this author Gennaro Musi More articles by this author Alberto Briganti More articles by this author Felix K. H. Chun More articles by this author Nicola Longo More articles by this author Pierre I. Karakiewicz More articles by this author Expand All Advertisement PDF downloadLoading ...