Mp42-03 Variations in Serum Sex Hormones and Semen Characteristics Following Clomiphene Citrate Treatment in Male Infertility

You have accessJournal of UrologyInfertility: Therapy (MP42)1 May 2024MP42-03 VARIATIONS IN SERUM SEX HORMONES AND SEMEN CHARACTERISTICS FOLLOWING CLOMIPHENE CITRATE TREATMENT IN MALE INFERTILITY Dar Yoffe, Vadim Osadchiy, Andre Belarmino, Tommy Jiang, Neilufar Modiri, Michael H. Zheng, Jesse Mills, and Sriram Eleswarapu Dar YoffeDar Yoffe , Vadim OsadchiyVadim Osadchiy , Andre BelarminoAndre Belarmino , Tommy JiangTommy Jiang , Neilufar ModiriNeilufar Modiri , Michael H. ZhengMichael H. Zheng , Jesse MillsJesse Mills , and Sriram EleswarapuSriram Eleswarapu View All Author Informationhttps://doi.org/10.1097/01.JU.0001008688.39367.31.03AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: The predictive metrics for assessing fertility outcomes following clomiphene citrate (CC) treatments are understudied. Our objective was to delineate the pre-treatment sex hormones that exhibit the strongest correlation with semen parameter improvements in CC-treated patients and to provide expected magnitude of improvement of key fertility parameters. METHODS: Our retrospective study involved 257 subfertile men who were administered CC for a duration of 3 months. Exclusion criteria included individuals with azoospermia, those with only a single semen analysis, those with a history of hormone therapy usage, or genitourinary intervention. Men were categorized into groups of at least ten patients based on their pre-treatment levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone/estradiol (T/E) ratio, and T/LH ratio. Primary outcomes investigated include absolute changes in total testosterone (TT), sperm concentration, and total sperm count. RESULTS: 134 patients met inclusion criteria. Pre-treatment FSH and LH were inversely correlated with improvements in TT (R2=0.67 and 0.41; p<0.001 for both), sperm concentration (R2=0.73 and 0.76; p=0.076 and p<0.001, respectively), and sperm count (R2=0.42 and 0.84, p=0.052 and<0.001, respectively). The T/E ratio exhibited a significant association with testosterone (p=0.0031), while the T/LH ratio did not demonstrate significant associations with any outcomes. Figure 1 provides the average magnitude of improvement of TT, sperm count, and sperm concentration by gonadotropin metrics of interest. CONCLUSIONS: Gonadotropin measurements are sufficient in predicting improvement in sperm parameters in men using CC for 3 months compared to ratio metrics. These data may also be useful for expectation management of magnitude of improvement of key fertility parameters. Download PPT Source of Funding: None © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e684 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Dar Yoffe More articles by this author Vadim Osadchiy More articles by this author Andre Belarmino More articles by this author Tommy Jiang More articles by this author Neilufar Modiri More articles by this author Michael H. Zheng More articles by this author Jesse Mills More articles by this author Sriram Eleswarapu More articles by this author Expand All Advertisement PDF downloadLoading ...