Mp51-14 Is Pathological Upstaging to T3a Renal Cell Carcinoma Associated With a Similar Prognosis to Non-Upstaged Pathologic T3a Disease? A Multicenter Analysis

You have accessJournal of UrologyKidney Cancer: Epidemiology pT3a-NUS 188; median follow-up 48 months]. MVA for ACM demonstrated increasing tumor size (HR 1.07, p=0.022), high-grade (HR 2.74, p<0.001) as independent risk factors. MVA for CSM demonstrated increasing tumor size (HR 1.11, p=0.005), high-grade (HR 2.36, p=0.003), and positive margin (HR 5.58, p=0.007) as independent predictors. MVA for recurrence revealed increasing tumor size (HR 1.05, p=0.05), high-grade (HR 3.55, p<0.001), and positive margin (HR 3.44, p<0.001) as independent predictors. pT3a-US was not an independent predictor in ACM (p=0.204), CSM (p=0.711), or recurrence (p=0.934). Comparing pT3a-NUS vs. pT3a-US, KMA revealed no difference in 5-year OS (60% vs. 62%, p=0.378), and worsened 5-year CSS and RFS were worse for pT3a-NUS (51% vs. 61%, p=0.04; 42% vs. 63%, p<0.001; Figure 1). CONCLUSIONS: Pathological upstaging is not an independent predictor of survival outcomes. In T3a RCC increasing tumor size and high-grade or presence of positive margin are main drivers of survival outcomes. Download PPT Source of Funding: Weissman Kidney Cancer Institute © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e847 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Jonathan Afari More articles by this author Ryan Nasseri More articles by this author Umberto Capitanio More articles by this author Cesare Saitta More articles by this author Riccardo Autorino More articles by this author Brian R. Lane More articles by this author Hajime Tanaka More articles by this author Kevin Hakimi More articles by this author Ava Saidian More articles by this author Michele Marchioni More articles by this author Dattatraya Patil More articles by this author Mimi V. Nguyen More articles by this author Dhruv Puri More articles by this author Jacob Roberts More articles by this author Margaret Meagher More articles by this author Kit Yuen More articles by this author Sabrina L. Noyes More articles by this author Chandru Sundaram More articles by this author Francesco Porpiglia More articles by this author James R. Porter More articles by this author Viraj Master More articles by this author Andrea Minervini More articles by this author Yasuhisa Fujii More articles by this author Francesco Montorsi More articles by this author Ithaar Derweesh More articles by this author Expand All Advertisement PDF downloadLoading ...