Mp67-14 Assessing the Impact on Postoperative Renal Function of Selective Embolization to Treat Arterial Bleedings After Partial Nephrectomy: Single Center Analysis

You have accessJournal of UrologyKidney Cancer: Localized: Surgical Therapy V (MP67)1 May 2024MP67-14 ASSESSING THE IMPACT ON POSTOPERATIVE RENAL FUNCTION OF SELECTIVE EMBOLIZATION TO TREAT ARTERIAL BLEEDINGS AFTER PARTIAL NEPHRECTOMY: SINGLE CENTER ANALYSIS Aldo Brassetti, Alfredo Maria Bove, Gabriele Tuderti, Riccardo Mastroianni, Leonardo Misuraca, Umberto Anceschi, Maria Consiglia Ferriero, Simone D'Annunzio, Salvatore Guaglianone, Michele Gallucci, Giuseppe Chiacchio, Rocco Simone Flammia, Flavia Proietti, Costantino Leonardo, and Giuseppe Simone Aldo BrassettiAldo Brassetti , Alfredo Maria BoveAlfredo Maria Bove , Gabriele TudertiGabriele Tuderti , Riccardo MastroianniRiccardo Mastroianni , Leonardo MisuracaLeonardo Misuraca , Umberto AnceschiUmberto Anceschi , Maria Consiglia FerrieroMaria Consiglia Ferriero , Simone D'AnnunzioSimone D'Annunzio , Salvatore GuaglianoneSalvatore Guaglianone , Michele GallucciMichele Gallucci , Giuseppe ChiacchioGiuseppe Chiacchio , Rocco Simone FlammiaRocco Simone Flammia , Flavia ProiettiFlavia Proietti , Costantino LeonardoCostantino Leonardo , and Giuseppe SimoneGiuseppe Simone View All Author Informationhttps://doi.org/10.1097/01.JU.0001009496.54470.10.14AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Selective arterial embolization (SAE) is an increasingly common therapeutic option for hemodynamically stable patients with post-partial nephrectomy (PN) haemorrhage. We investigated its impact on functional outcomes after nephron-sparing surgery. METHODS: our prospectively maintained database was searched for patients that required SAE to treat haemorrhage after PN, from January 2012 onwards. Their baseline characteristics and perioperative outcomes were collected and compared to those of a continuous series of individuals undergone PN with an uneventful postoperative course. The χ2 and Mann-Whitney tests were used for categorical and continuous variables, respectively. Logistic regression analyses assessed predictors of a significant renal function deterioration (sFRD), defined as ≧ 30% reduction of the estimated glomerular filtration rate (eGFR) at discharge. Kaplan Mayer (KM) analysis estimated the probabilities of developing, during follow-up, a worsening of the Chronic Kidney Disease (CKD) stage, compared to baseline values; the Log Rank test compared results in the two cohorts. RESULTS: Overall, 343 patients were included in the analysis: 12 in the SAE cohort and 331 in the control group. Patients' and tumors' characteristics were comparable at baseline (all p>0.07) (Table 1). The rate of postoperative sRFD was significantly higher among embolized patients (42% vs 6%; p<0.001) (Figure 1) and embolization was the only independent predictor of sRFD development (OR: 9.63; 95% CI: 2.75-33.7; p<0.001) (Table 2). KM analysis failed to identify any difference in the two cohorts concerning CKD progression at follow-up (Log Rank=0.13) (Figure 1). CONCLUSIONS: SAE has a significant impact on post-PN eGFR and remarkably increases the risk of sRFD but such a detrimental effect seems limited to the early postoperative period. Download PPT Source of Funding: None © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e1103 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Aldo Brassetti More articles by this author Alfredo Maria Bove More articles by this author Gabriele Tuderti More articles by this author Riccardo Mastroianni More articles by this author Leonardo Misuraca More articles by this author Umberto Anceschi More articles by this author Maria Consiglia Ferriero More articles by this author Simone D'Annunzio More articles by this author Salvatore Guaglianone More articles by this author Michele Gallucci More articles by this author Giuseppe Chiacchio More articles by this author Rocco Simone Flammia More articles by this author Flavia Proietti More articles by this author Costantino Leonardo More articles by this author Giuseppe Simone More articles by this author Expand All Advertisement PDF downloadLoading ...