Pd28-06 the Effect of Combination Treatment With Low-Intensity Shockwave Therapy and Daily Low-Dose Tadalafil on Severe Erectile Dysfunction: A Double-Blind, Randomized, Sham-Controlled Clinical Trial

You have accessJournal of UrologySexual Function/Dysfunction: Evaluation I (PD28)1 May 2024PD28-06 THE EFFECT OF COMBINATION TREATMENT WITH LOW-INTENSITY SHOCKWAVE THERAPY AND DAILY LOW-DOSE TADALAFIL ON SEVERE ERECTILE DYSFUNCTION: A DOUBLE-BLIND, RANDOMIZED, SHAM-CONTROLLED CLINICAL TRIAL Dimitrios Kalyvianakis, Ioannis Mykoniatis, Nikolaos Pyrgidis, Paraskeui Kapoteli, Filimon Zilotis, and Dimitrios Hatzichristou Dimitrios KalyvianakisDimitrios Kalyvianakis , Ioannis MykoniatisIoannis Mykoniatis , Nikolaos PyrgidisNikolaos Pyrgidis , Paraskeui KapoteliParaskeui Kapoteli , Filimon ZilotisFilimon Zilotis , and Dimitrios HatzichristouDimitrios Hatzichristou View All Author Informationhttps://doi.org/10.1097/01.JU.0001009380.44020.d3.06AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: To assess the role of combination therapy with low-intensity shockwave therapy (LiST) and tadalafil on severe vasculogenic erectile dysfunction (ED) through a double-blind, randomized trial. METHODS: Forty-eight sexually active males were randomly assigned to twelve sessions of LiST three times weekly and tadalafil 5 mg once daily (n=33) or sham-therapy and tadalafil (n=15) for four weeks. Patients were assessed at one and three months after completion of treatment. Improvement of erectile function was evaluated through the International Index of Erectile Function – Erectile Domain (IIEF-EF) and the Sexual Encounter Profile (SEP) diaries. The number of patients attaining a minimal clinically important difference (MCID) in the IIEF-EF, as well as the safety of treatment were also assessed. RESULTS: Adjusting for the baseline values, IIEF-EF improved by 3.1 points (95%CI: 2-4.3, p<0.001) at one month and 3.2 points (95%CI: 2.1-4.3, p<0.001) at three months in patients receiving LiST and tadalafil versus sham-therapy and tadalafil. Between the two groups, the proportion of "yes" responses to question 3 of SEP diaries was not statistically significant, whereas the number of patients attaining a MCID in the IIEF-EF was statistically significant only at the 3-month evaluation. No adverse events occurred. CONCLUSIONS: Combination of LiST three times weekly and daily, low dose tadalafil for four weeks may further ameliorate severe vasculogenic ED compared to tadalafil monotherapy, without compromising safety. Nevertheless, additional high-quality trials are mandatory to corroborate our findings. Download PPT Source of Funding: None © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e614 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Dimitrios Kalyvianakis More articles by this author Ioannis Mykoniatis More articles by this author Nikolaos Pyrgidis More articles by this author Paraskeui Kapoteli More articles by this author Filimon Zilotis More articles by this author Dimitrios Hatzichristou More articles by this author Expand All Advertisement PDF downloadLoading ...