Mp66-15 Daily Treatment With the Puberty Blocker, Leuprolide Acetate, Reduces Sex Differences and Lowers Anxiety-Like Behavior in Juvenile Rats

You have accessJournal of UrologySexual Function/Dysfunction: Basic Research treatment: p=0.007). Leuprolide lowered FSH levels (p=0.028) and eliminated sex differences in growth hormone, thyroid stimulating hormone, testosterone, androstenedione, and corticosterone levels (p<0.001). In the amygdala, control females have higher levels of Arc mRNA than control males (p=0.006), and leuprolide eliminated this sex difference by elevated levels in males (p=0.001). Leuprolide treatment delayed vaginal opening in female rats (p=0.0002). CONCLUSIONS: Leuprolide treatment reduced anxiety-like behavior and eliminated sex differences in rough-and-tumble play behavior and ARC mRNA levels within the adolescent amygdala. These findings have clinical relevance for TNB youth receiving GAHC, as it contributes to the intended use of puberty blockers in stopping sex differences from developing further with the potential benefit of lowering anxiety-like behavior. Further examination with long-term studies in conjunction with other GAHC is required to better understand clinical implications of Leuprolide treatment. Source of Funding: Collaborative Health Sciences Program Grant, Wisconsin Partnership Program © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e1091 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Gabriela de Faria Oliveira More articles by this author Leykza Carreras Simons-Kristin Ebert More articles by this author Thomas Niepsuj More articles by this author Amber T. Nguyen More articles by this author Salma H. Gadelhak More articles by this author Aimee K. Johnson More articles by this author Ashwakh Abdalla More articles by this author Eden Lev More articles by this author Sofia G. Torres Roman More articles by this author Joan S. Jorgensen More articles by this author Walid A. Farhat More articles by this author Anthony Auger More articles by this author Expand All Advertisement PDF downloadLoading ...