Mp11-19 Incidence and Risk Factors for Post-Operative Infections After Robotic-Assisted Radical Prostatectomy (Rarp) in a Single Large Institution: Effect of Type and Duration of Prophylactic Antibiotic Administration

You have accessJournal of UrologyInfections/Inflammation/Cystic Disease of the Genitourinary Tract: Prostate & Genitalia (MP11)1 May 2024MP11-19 INCIDENCE AND RISK FACTORS FOR POST-OPERATIVE INFECTIONS AFTER ROBOTIC-ASSISTED RADICAL PROSTATECTOMY (RARP) IN A SINGLE LARGE INSTITUTION: EFFECT OF TYPE AND DURATION OF PROPHYLACTIC ANTIBIOTIC ADMINISTRATION Takuya Sadahira and Motoo Araki Takuya SadahiraTakuya Sadahira and Motoo ArakiMotoo Araki View All Author Informationhttps://doi.org/10.1097/01.JU.0001008564.85995.11.19AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: We evaluated the incidence and risk factors for post-operative infections after Robotic-Assisted Radical Prostatectomy (RARP) according to the effect of type and duration of prophylactic antibiotic administration. METHODS: A total of 1038 patients who underwent RARP at our institution from October 2010 to August 2021 were included in this study. Patients were classified by type of prophylactic antimicrobial agents. 1026 patients (199 in the Cefazolin (CEZ) group and 839 in the Ampicillin/Sulbactam (ABPC/SBT) group) were investigated, and 12 patients who used the other antibiotics because of pre-operative urine culture results or history of allergy were excluded. The primary endpoint was the incidence of urinary tract infection (UTI), surgical site infection (SSI), and remote infection (RI) within 30 days after surgery. T-tests were performed between the two groups. To overcome biases from the different distribution of covariates among patients in the two study groups, a propensity score analysis was performed. Multivariate logistic regression analysis was performed to evaluate the effect of type and duration of prophylactic antibiotic administration. RESULTS: In the 1026 patients, the incidence of UTI was 2.5% (5/199) in the CEZ group and 3.1% (26/827) in the ABPC/SBT group, with no significant difference between the two groups (p=0.663). The incidence of SSI and RI were not significantly different as well (p=0.756, 0.697). Although the duration of antimicrobial therapy tended to be significantly longer in the CEZ group (p<0.001), there was no significant difference in the incidence of UTI/SSI/RI after propensity score matching (p=1.000). Multivariate logistic regression analysis also showed that neither the type of antibiotics nor the duration of administration affected the incidence of UTI/SSI/RI. CONCLUSIONS: The risk of UTI/SSI/RI after RARP did not change with the type and duration of antimicrobial therapy. Source of Funding: None © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e158 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Takuya Sadahira More articles by this author Motoo Araki More articles by this author Expand All Advertisement PDF downloadLoading ...