Pd35-06 Association of a Polygenetic Risk Score and Prostate Cancer Detection

You have accessJournal of UrologyProstate Cancer: Basic Research PSA 6.2ng/mL; PSA density (PSAD) 0.12ng/mL2; Race/ethnicity, non-Hispanic white 62%, Hispanic 11%, Asian 16%, Black 8.5%; PIRADS 1-2 23%, PIRADS 3 19%, PIRADS 4 34%, and PIRADS 5 23%. The distribution of the highest GG on PBx was, benign 36%, GG1 19%, GG2 20%, GG3 9.5%, GG4 7.6%, and GG5 6.5%. On multivariable logistic regression, PRS (Odds ratio OR 1.70, 95%CI 1.30-2.23), age (OR 1.06, 95%CI 1.02-1.10), PSAD per 0.01 (OR 1.07, 95%CI 1.03-1.10), and PIRADS 3-5 (OR 3.12, 95%CI 1.73-5.61) were independent predictors for PCa detection. The addition of PRS in the non-invasive and pre-PBx predictors improved the area under the ROC curve (0.74 to 0.78), sensitivity (69% to 74%), and specificity (67% to 69%). CONCLUSIONS: A novel and non-invasive polygenetic risk score successfully predicted the presence of prostate cancer from saliva samples in the prospective study. Combined with non-invasive pre-biopsy patient characteristics, prostate cancer can be predicted. Download PPT Source of Funding: This study was supported by NCI P30 Cancer Center Support Grant (P30CA0140890) © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e726 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Masatomo Kaneko More articles by this author David Bogumil More articles by this author Lorenzo Storino Ramacciotti More articles by this author Peggy Wan More articles by this author Manju Aron More articles by this author David Conti More articles by this author Michelle Hopstone More articles by this author Inderbir S. Gill More articles by this author Christopher Haiman More articles by this author Andre Luis Abreu More articles by this author Expand All Advertisement PDF downloadLoading ...