Pd57-01 Prostatic Urethral Length on Mri Potentially Predicts Late Genitourinary Toxicity After Radiation for Prostate Cancer

You have accessJournal of UrologyProstate Cancer: Localized: Radiation Therapy (PD57)1 May 2024PD57-01 PROSTATIC URETHRAL LENGTH ON MRI POTENTIALLY PREDICTS LATE GENITOURINARY TOXICITY AFTER RADIATION FOR PROSTATE CANCER David Gangwish, Joseph Lee, Sirisha Nandalur, Allison Hazy, Sayf Al-Katib, Kyu Kim, Hong Ye, Nathan Kolderman, Abhay Dhaliwal, Daniel Krauss, Thomas Quinn, Kimberly Marvin, and Kiran Nandalur David GangwishDavid Gangwish , Joseph LeeJoseph Lee , Sirisha NandalurSirisha Nandalur , Allison HazyAllison Hazy , Sayf Al-KatibSayf Al-Katib , Kyu KimKyu Kim , Hong YeHong Ye , Nathan KoldermanNathan Kolderman , Abhay DhaliwalAbhay Dhaliwal , Daniel KraussDaniel Krauss , Thomas QuinnThomas Quinn , Kimberly MarvinKimberly Marvin , and Kiran NandalurKiran Nandalur View All Author Informationhttps://doi.org/10.1097/01.JU.0001008808.16085.aa.01AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: To evaluate pretreatment prostate quantitative magnetic resonance imaging (MRI) measurements and clinical characteristics for predicting genitourinary (GU) toxicity after radiotherapy (RT) for prostate cancer (PCa). METHODS: In a single institution, retrospective cohort study, we evaluated patients with PCa who had MRI within 6 months of RT from June 2016 to February 2023. MRI measurements included quantitative urethra, prostate, and bladder measurements. The Common Terminology Criteria for Adverse Events (CTCAE v4.0) was used with late toxicity defined as >180 days. Univariable and multivariable Cox proportional hazard models were used for late toxicity, adjusted for clinical factors and RT method. RESULTS: A total of 361 men (median age 68 years, interquartile range (IQR) 62-73) were included. Rates of grade ≥2 GU toxicity were 11.3%, 23.6%, and 28% at year 1, 2, and 3, respectively. Prostatic urethral length had a median of 4.6cm with an IQR of 4.1-5.1cm. Only longer prostatic urethral length (hazard ratio (HR):1.6, 95%CI: 1.2-2.1, p<0.01) was associated with increased risk of late GU toxicity, notably urinary frequency/urgency symptoms (HR: 1.7 (95%CI: 1.3-2.3), p<0.01). Of note, pretreatment AUA score was not statistically significant. CONCLUSIONS: Longer prostatic urethral length measured on prostate MRI is independently associated with higher risk of developing late grade ≥2 GU toxicity after radiation therapy for PCa. This pretreatment metric may be potentially valuable in risk-stratification models for patients considering radiation therapy vs prostatectomy. Download PPT Source of Funding: None © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e1208 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information David Gangwish More articles by this author Joseph Lee More articles by this author Sirisha Nandalur More articles by this author Allison Hazy More articles by this author Sayf Al-Katib More articles by this author Kyu Kim More articles by this author Hong Ye More articles by this author Nathan Kolderman More articles by this author Abhay Dhaliwal More articles by this author Daniel Krauss More articles by this author Thomas Quinn More articles by this author Kimberly Marvin More articles by this author Kiran Nandalur More articles by this author Expand All Advertisement PDF downloadLoading ...