0690 Clinical Outcomes in Adults with Comorbid Restless Legs Syndrome and Obstructive Sleep Apnea (CO-ROSA)

Abstract Introduction Obstructive sleep apnea (OSA) and restless legs syndrome (RLS) both significantly influence important measures of health in adults. The Patient Health Questionnaire (PHQ-9), Epworth Sleepiness Scale (ESS), Insomnia Severity Index (ISI), and Generalized Anxiety Disorder 7 (GAD-7) questionnaires assess depression, sleepiness, insomnia, and anxiety symptoms, respectively. We hypothesized that patients with comorbid RLS and OSA (CO-ROSA) will show worse scores in the above-mentioned questionnaires, than patients with OSA alone. Methods In this observational cross-sectional study, we administered PHQ-9, ESS, ISI, GAD-7 to adult patients with OSA and patients with CO-ROSA, both treated with CPAP, at a single academic sleep center. Inclusion criteria: presence of OSA or CO-ROSA treated with CPAP. Exclusion criteria: diagnosis of narcolepsy, REM behavior disorder, dementia, or unable to communicate (answer the questionnaire). Data collected included demographics (age, sex, self-reported ethnicity), presence of comorbid restless legs syndrome, and polysomnographic data. SPSS was used to obtain descriptive statistics, independent T-Tests, and Pearson correlation. P-values of 0.05 were significant. Results A total of 133 patients were included in the study, 53.4% had OSA alone (OSA) and 46.6% had Co-ROSA. Demographics: White 62.3%, Latino 27.4, Black 5%, and Asian 1.4%. 37% of Latino and 45 % of whites had CO-ROSA. There were no statistically significant differences in age, AHI, polysomnographic parameters, and CPAP adherence between OSA and CO-ROSA groups. Patients with CO-ROSA had higher PHQ-9 scores (8.2±5.1) than patients with OSA alone (5.2±5.6) and higher ESS (9.5 ±5.7) than OSA (5.9±4.5); (p 0.05); The following did not reach statistical significance: ISI in OSA (14.85±7.9) and CO-ROSA (14.57±6.1); GAD-7 in OSA (4.29±5.1) and CO-ROSA (5.76±4.5). Latino participants had lower PHQ-9 scores (4.71±4.9), p 0.05. There were no correlations between any of the questionnaire scores with age, severity of OSA, compliance, or polysomnographic parameters. Conclusion Patients with CO-ROSA have statistically significant worse measures of depression and sleepiness than those with OSA alone despite equal compliance, age, polysomnographic parameters, and OSA severity. Both groups had elevated ISI scores. As a whole group Latino patients had lower symptoms of depression. Support (if any)